Cotton leaf curl Multan virus

Basic Information

Genus Begomovirus
NCBI Assembly GCF_000839845.1
Isolate India: Rajasthan, Sriganganagar
Release date 2015/2/12
Submitter Radhakrishnan,G., Malathi,V.G., Varma,A.
Host
Download Genome |GFF3 |PEP |CDS

Genomic Organization

JBrowse

Genome

NC_003199
ACCGGATGGCCGCGCGATTTTTTTGGTGGGCCTTACCATTAACACTTGTCGGCCAATCATATGACTCCCTCAAAGCTAAATAACGCTCCCGCACACTATAAGTACTTGCGCACTAAGTTTCAAATTCAAACATGTGGGATCCACTATTAAACGAATTCCCTGATACGGTTCACGGGTTTCGGTGTATGCTTTCTGTGAAATATTTGCAACTTTTGTCGCAGGATTATTCACCGGATACGCTTGGGTACGAGTTAATACGGGATTTAATTTGTATTTTACGCTCCCGTAGTTATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAGAGGATGTGAAGGTCCATGTAAGGTTCAGTCGTTTGAGTCCAGACATGATATTCAGCATATAGGTAAAGTAATGTGTGTTAGTGATGTTACTCGTGGTACTGGGCTGACCCATAGAGTTGGTAAGAGATTTTGTGTCAAGTCTGTTTATGTGTTGGGTAAGATATGGATGGATGAGAACATTAAGACGAAGAATCACACGAATAGTGTGATGTTTTTCTTGGTTAGAGATCGTAGACCTGTTGATAAACCTCAAGATTTTGGAGAGGTATTTAATATGTTTGATAATGAGCCCAGTACGGCGACTGTGAAGAATGTTCATCGTGATAGGTATCAAGTTCTGCGCAAATGGTATGCAACTGTCACCGGTGGACAATACGCTTCAAAGGAACAGGCTTTGGTCAAGAAGTTTGTCAGAGTTAACAATTATGTTGTTTACAATCAACAGGAAGCAGGAAAATACGAGAATCATACGGAAAATGCGTTAATGCTTTATATGGCTTGTACTCACGCTAGCAACCCTGTTTATGCTACGTTGAAGATTAGGATATATTTTTATGACTCTGTAACGAATTGATATTAATAAAGTTTAAATTTTATTTCTGAATATTGATCTACATACATAGTTTGTTGGATTACATTGTACAATACATGTTCTACAGCTTTAATAACTAAATTAATTGAAATTACACCGAGATTGTTCAGATATTTGAGGACTTGGTTTTTGAATACCCTTAAGAAAAGACCAGTCTGAGGCTGTAAGGTCGTCCAGATTCGGAAGGTTAGAAAACACTTGTGCAGTCCCAGAGCTTTCCGCGTGTTGTAGTTGAACTGGATCCTGATCGTGAGTATGTCCATATTCGTCGTGAATGGACGGTTGACGTGGCTGATGATCTTGAAATAAAGGGGATTTGGAACCTCCCAGATATATGCGCCATTCCCTGCTTGAGCTGCAGTGATGGGTTCCCCTGTGCGTGAATCCATGGTTGTGGCAGTTGATTGACAGATAATAAGAACACCCGCATTCAAGATCTACTCTCCTCCTCCTGTTGCGCCTCTTCGCTTCCCTGTGCTGTACTTTGATTGGTACCTGAGTACATGGGTCTATCAAGTGTGATGAAGATCGCATTCTTTAAAGCCCAATTTTTTAGTGCAGAATTCTTCTCTTCATCCAAAAACTCTTTATAGCTAGAATTGGGTCCTGGATTGCAGAGGAAGATGGTGGGAATTCCGCCTTTAATTTGAACTGGCTTCCCGTATTTTGTATTTGATTGCCAGTCCTTTTGGGCCCCCATGAACTCCTTAAAGTGCTTTAGGTAATGTGGGTTGACGTCATCAATGACGTTAAACCAGGCGTCATTACTGTATACCCTTGGGCTCAGATCTAGATGTCCACACAGATAATTATGTGGACCTAATGATCTGGCCCACATCGTCTTCCCCGTCCTACTGTCACCCTCAATCACTACACTTATTGGTCTATTGGCCCGCGCAGCGGCACTGACGACGTTCTCGGCAGCCCACACTTCAAGTTCTTCTGGAACTTGATCGAAAGAAGAAGAGGAAAAAGGAGAAACATAAGGAGCTGGTGGCTCCTGAAAGATTCTGTCTAGATTTGCATTTAAATTATGAAATTGCAGTACAAAATCCTTAGGAGCTAGTTCCTTAATGACTCTAAGAGCCTCCGACTTACTTCCCGCGTTAAGTGCTGCGGCGTAAGCGTCATTGGCTGTCTGTTGCCCTCCTCTTGCTGACCTTCCGTCGATCTGAAATTGCCCCCAGTCGAGAATGTCCCCGTCCTTCTCGGTGTAGGATTTGACGTCGGAGCTGGATTTAGCTCCCTGTATGTTCGGATGGAAATGTGCTGACCTGCTTGGGGAGACCAAGTCGAAGAATCGCATATTCTGGCACTTGAAATTCCCTTCGAACTGGATGAGAACATGCAAGTGAGGAGTCCCATCTTCGTGAAGCTCTCTGCAGATTCTAATATATTTTTTTGAAGTTGGGGTTTGTATATTTAATAATTGGGAAAGTGCTTCCTCTTTGGTGAGAGAACATTTGGGATAAGTGATGAAATAGTTTTTGGAATAAATACCGTTCCGCTTTGGAGGCATGTTGACTAAAATTGATCACCGATTGACCGCTCTTGCAACTCTCCCCGGTATATCGGTGATCAATATATAGTGATCACCAAATGGCATAATGGTAATAAAAAAACTTTAATTTGAAATTCAAACCAAAAGGCTAAAGCGGCCATCCGTTTAATATT

Gene Information

NCBI Accession NP_443740.1
Location 132-488
Gene Name AV2
Protein Name movement/pre-coat protein
Coding Region ATGTGGGATCCACTATTAAACGAATTCCCTGATACGGTTCACGGGTTTCGGTGTATGCTTTCTGTGAAATATTTGCAACTTTTGTCGCAGGATTATTCACCGGATACGCTTGGGTACGAGTTAATACGGGATTTAATTTGTATTTTACGCTCCCGTAGTTATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAG
Protein Sequence MWDPLLNEFPDTVHGFRCMLSVKYLQLLSQDYSPDTLGYELIRDLICILRSRSYVEASCRYRHFYARVESTPASELRQPIHQPCCCPHCPRHKTTGMDKQAYEQEAQDVQDVQKSRCS

NCBI Accession NP_443741.1
Location 292-1062
Gene Name AV1
Protein Name coat protein
Coding Region ATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAGAGGATGTGAAGGTCCATGTAAGGTTCAGTCGTTTGAGTCCAGACATGATATTCAGCATATAGGTAAAGTAATGTGTGTTAGTGATGTTACTCGTGGTACTGGGCTGACCCATAGAGTTGGTAAGAGATTTTGTGTCAAGTCTGTTTATGTGTTGGGTAAGATATGGATGGATGAGAACATTAAGACGAAGAATCACACGAATAGTGTGATGTTTTTCTTGGTTAGAGATCGTAGACCTGTTGATAAACCTCAAGATTTTGGAGAGGTATTTAATATGTTTGATAATGAGCCCAGTACGGCGACTGTGAAGAATGTTCATCGTGATAGGTATCAAGTTCTGCGCAAATGGTATGCAACTGTCACCGGTGGACAATACGCTTCAAAGGAACAGGCTTTGGTCAAGAAGTTTGTCAGAGTTAACAATTATGTTGTTTACAATCAACAGGAAGCAGGAAAATACGAGAATCATACGGAAAATGCGTTAATGCTTTATATGGCTTGTACTCACGCTAGCAACCCTGTTTATGCTACGTTGAAGATTAGGATATATTTTTATGACTCTGTAACGAATTGA
Protein Sequence MSKRAADIVISTPASKVRRRLNFGSPYTSRAAAPIVRVTKQQAWTNRPMNRKPRMYRMYRSPDVPRGCEGPCKVQSFESRHDIQHIGKVMCVSDVTRGTGLTHRVGKRFCVKSVYVLGKIWMDENIKTKNHTNSVMFFLVRDRRPVDKPQDFGEVFNMFDNEPSTATVKNVHRDRYQVLRKWYATVTGGQYASKEQALVKKFVRVNNYVVYNQQEAGKYENHTENALMLYMACTHASNPVYATLKIRIYFYDSVTN

NCBI Accession NP_443742.1
Location 1065-1469
Gene Name AC3
Protein Name replication enhancer protein
Coding Region ATGGATTCACGCACAGGGGAACCCATCACTGCAGCTCAAGCAGGGAATGGCGCATATATCTGGGAGGTTCCAAATCCCCTTTATTTCAAGATCATCAGCCACGTCAACCGTCCATTCACGACGAATATGGACATACTCACGATCAGGATCCAGTTCAACTACAACACGCGGAAAGCTCTGGGACTGCACAAGTGTTTTCTAACCTTCCGAATCTGGACGACCTTACAGCCTCAGACTGGTCTTTTCTTAAGGGTATTCAAAAACCAAGTCCTCAAATATCTGAACAATCTCGGTGTAATTTCAATTAATTTAGTTATTAAAGCTGTAGAACATGTATTGTACAATGTAATCCAACAAACTATGTATGTAGATCAATATTCAGAAATAAAATTTAAACTTTATTAA
Protein Sequence MDSRTGEPITAAQAGNGAYIWEVPNPLYFKIISHVNRPFTTNMDILTIRIQFNYNTRKALGLHKCFLTFRIWTTLQPQTGLFLRVFKNQVLKYLNNLGVISINLVIKAVEHVLYNVIQQTMYVDQYSEIKFKLY

NCBI Accession NP_443743.1
Location 1162-1614
Gene Name AC2
Protein Name transcription activator protein
Coding Region ATGCGATCTTCATCACACTTGATAGACCCATGTACTCAGGTACCAATCAAAGTACAGCACAGGGAAGCGAAGAGGCGCAACAGGAGGAGGAGAGTAGATCTTGAATGCGGGTGTTCTTATTATCTGTCAATCAACTGCCACAACCATGGATTCACGCACAGGGGAACCCATCACTGCAGCTCAAGCAGGGAATGGCGCATATATCTGGGAGGTTCCAAATCCCCTTTATTTCAAGATCATCAGCCACGTCAACCGTCCATTCACGACGAATATGGACATACTCACGATCAGGATCCAGTTCAACTACAACACGCGGAAAGCTCTGGGACTGCACAAGTGTTTTCTAACCTTCCGAATCTGGACGACCTTACAGCCTCAGACTGGTCTTTTCTTAAGGGTATTCAAAAACCAAGTCCTCAAATATCTGAACAATCTCGGTGTAATTTCAATTAA
Protein Sequence MRSSSHLIDPCTQVPIKVQHREAKRRNRRRRVDLECGCSYYLSINCHNHGFTHRGTHHCSSSREWRIYLGGSKSPLFQDHQPRQPSIHDEYGHTHDQDPVQLQHAESSGTAQVFSNLPNLDDLTASDWSFLKGIQKPSPQISEQSRCNFN

NCBI Accession NP_443744.1
Location 1511-2599
Gene Name AC1
Protein Name replication initiator protein
Coding Region ATGCCTCCAAAGCGGAACGGTATTTATTCCAAAAACTATTTCATCACTTATCCCAAATGTTCTCTCACCAAAGAGGAAGCACTTTCCCAATTATTAAATATACAAACCCCAACTTCAAAAAAATATATTAGAATCTGCAGAGAGCTTCACGAAGATGGGACTCCTCACTTGCATGTTCTCATCCAGTTCGAAGGGAATTTCAAGTGCCAGAATATGCGATTCTTCGACTTGGTCTCCCCAAGCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAATCCTACACCGAGAAGGACGGGGACATTCTCGACTGGGGGCAATTTCAGATCGACGGAAGGTCAGCAAGAGGAGGGCAACAGACAGCCAATGACGCTTACGCCGCAGCACTTAACGCGGGAAGTAAGTCGGAGGCTCTTAGAGTCATTAAGGAACTAGCTCCTAAGGATTTTGTACTGCAATTTCATAATTTAAATGCAAATCTAGACAGAATCTTTCAGGAGCCACCAGCTCCTTATGTTTCTCCTTTTTCCTCTTCTTCTTTCGATCAAGTTCCAGAAGAACTTGAAGTGTGGGCTGCCGAGAACGTCGTCAGTGCCGCTGCGCGGGCCAATAGACCAATAAGTGTAGTGATTGAGGGTGACAGTAGGACGGGGAAGACGATGTGGGCCAGATCATTAGGTCCACATAATTATCTGTGTGGACATCTAGATCTGAGCCCAAGGGTATACAGTAATGACGCCTGGTTTAACGTCATTGATGACGTCAACCCACATTACCTAAAGCACTTTAAGGAGTTCATGGGGGCCCAAAAGGACTGGCAATCAAATACAAAATACGGGAAGCCAGTTCAAATTAAAGGCGGAATTCCCACCATCTTCCTCTGCAATCCAGGACCCAATTCTAGCTATAAAGAGTTTTTGGATGAAGAGAAGAATTCTGCACTAAAAAATTGGGCTTTAAAGAATGCGATCTTCATCACACTTGATAGACCCATGTACTCAGGTACCAATCAAAGTACAGCACAGGGAAGCGAAGAGGCGCAACAGGAGGAGGAGAGTAGATCTTGA
Protein Sequence MPPKRNGIYSKNYFITYPKCSLTKEEALSQLLNIQTPTSKKYIRICRELHEDGTPHLHVLIQFEGNFKCQNMRFFDLVSPSRSAHFHPNIQGAKSSSDVKSYTEKDGDILDWGQFQIDGRSARGGQQTANDAYAAALNAGSKSEALRVIKELAPKDFVLQFHNLNANLDRIFQEPPAPYVSPFSSSSFDQVPEELEVWAAENVVSAAARANRPISVVIEGDSRTGKTMWARSLGPHNYLCGHLDLSPRVYSNDAWFNVIDDVNPHYLKHFKEFMGAQKDWQSNTKYGKPVQIKGGIPTIFLCNPGPNSSYKEFLDEEKNSALKNWALKNAIFITLDRPMYSGTNQSTAQGSEEAQQEEESRS

NCBI Accession NP_443745.1
Location 2143-2445
Gene Name AC4
Protein Name AC4
Coding Region ATGGGACTCCTCACTTGCATGTTCTCATCCAGTTCGAAGGGAATTTCAAGTGCCAGAATATGCGATTCTTCGACTTGGTCTCCCCAAGCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAATCCTACACCGAGAAGGACGGGGACATTCTCGACTGGGGGCAATTTCAGATCGACGGAAGGTCAGCAAGAGGAGGGCAACAGACAGCCAATGACGCTTACGCCGCAGCACTTAACGCGGGAAGTAAGTCGGAGGCTCTTAGAGTCATTAAGGAACTAG
Protein Sequence MGLLTCMFSSSSKGISSARICDSSTWSPQAGQHISIRTYRELNPAPTSNPTPRRTGTFSTGGNFRSTEGQQEEGNRQPMTLTPQHLTREVSRRLLESLRN

References More References in PubMed

1

Cotton leaf curl Multan virus subverts the processing of hydroxyproline-rich systemin to suppress tobacco defenses against insect vectors.

Chen N, et al.  J Exp Bot. 2024 Sep 27;75(18):5819-5838. doi: 10.1093/jxb/erae257.

PMID: 38829390
2

LbCas12a mediated suppression of Cotton leaf curl Multan virus.

Ashraf S, et al.  Front Plant Sci. 2023 Aug 11;14:1233295. doi: 10.3389/fpls.2023.1233295. eCollection 2023.

PMID: 37636103
3

Cotton leaf curl Multan virus C4 protein suppresses autophagy to facilitate viral infection.

Yang M, et al.  Plant Physiol. 2023 Aug 31;193(1):708-720. doi: 10.1093/plphys/kiad235.

PMID: 37073495
4

Comparative transcriptome analysis of whiteflies raised on cotton leaf curl Multan virus-infected cotton plants.

Chen T, et al.  Front Vet Sci. 2024 Aug 28;11:1417590. doi: 10.3389/fvets.2024.1417590. eCollection 2024.

PMID: 39263677
5

Cotton leaf curl Multan virus activates autophagy in the whitefly AsiaII7, weakening its vectorial capacity for transmission.

Chen T, et al.  Pest Manag Sci. 2025 Jun;81(6):3039-3047. doi: 10.1002/ps.8674. Epub 2025 Jan 28.

PMID: 39871813
6

Dominance of Cotton leaf curl Multan virus-Rajasthan strain associated with third epidemic of cotton leaf curl disease in Pakistan.

Mahmood MA, et al.  Sci Rep. 2024 Jun 12;14(1):13532. doi: 10.1038/s41598-024-63211-8.

PMID: 38866855
7

In Silico Investigation of the Interactions Between Cotton Leaf Curl Multan Virus Proteins and the Transcriptional Gene Silencing Factors of Gossypium hirsutum L.

Jain H, et al.  J Mol Evol. 2024 Dec;92(6):891-911. doi: 10.1007/s00239-024-10216-6. Epub 2024 Nov 14.

PMID: 39542922
8

Prevalence, transmission and molecular characterization of Cotton leaf curl Multan virus infecting hollyhock plants in Pakistan.

Azeem H, et al.  Mol Biol Rep. 2022 Jun;49(6):5635-5644. doi: 10.1007/s11033-022-07557-0. Epub 2022 May 22.

PMID: 35598198
9

Elicitor-Driven Defense Mechanisms: Shielding Cotton Plants against the Onslaught of Cotton Leaf Curl Multan Virus (CLCuMuV) Disease.

Khan MF, et al.  Metabolites. 2023 Nov 12;13(11):1148. doi: 10.3390/metabo13111148.

PMID: 37999244
10

An Insight into Cotton Leaf Curl Multan Betasatellite, the Most Important Component of Cotton Leaf Curl Disease Complex.

Zubair M, et al.  Viruses. 2017 Sep 29;9(10):280. doi: 10.3390/v9100280.

PMID: 28961220