Cotton leaf curl Multan virus

Basic Information

Genus Begomovirus
NCBI Assembly GCF_000839845.1
Isolate India: Rajasthan, Sriganganagar
Release date 2015/2/12
Submitter Radhakrishnan,G., Malathi,V.G., Varma,A.
Host
Download Genome |GFF3 |PEP |CDS

Genomic Organization

JBrowse

Genome

NC_003199
ACCGGATGGCCGCGCGATTTTTTTGGTGGGCCTTACCATTAACACTTGTCGGCCAATCATATGACTCCCTCAAAGCTAAATAACGCTCCCGCACACTATAAGTACTTGCGCACTAAGTTTCAAATTCAAACATGTGGGATCCACTATTAAACGAATTCCCTGATACGGTTCACGGGTTTCGGTGTATGCTTTCTGTGAAATATTTGCAACTTTTGTCGCAGGATTATTCACCGGATACGCTTGGGTACGAGTTAATACGGGATTTAATTTGTATTTTACGCTCCCGTAGTTATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAGAGGATGTGAAGGTCCATGTAAGGTTCAGTCGTTTGAGTCCAGACATGATATTCAGCATATAGGTAAAGTAATGTGTGTTAGTGATGTTACTCGTGGTACTGGGCTGACCCATAGAGTTGGTAAGAGATTTTGTGTCAAGTCTGTTTATGTGTTGGGTAAGATATGGATGGATGAGAACATTAAGACGAAGAATCACACGAATAGTGTGATGTTTTTCTTGGTTAGAGATCGTAGACCTGTTGATAAACCTCAAGATTTTGGAGAGGTATTTAATATGTTTGATAATGAGCCCAGTACGGCGACTGTGAAGAATGTTCATCGTGATAGGTATCAAGTTCTGCGCAAATGGTATGCAACTGTCACCGGTGGACAATACGCTTCAAAGGAACAGGCTTTGGTCAAGAAGTTTGTCAGAGTTAACAATTATGTTGTTTACAATCAACAGGAAGCAGGAAAATACGAGAATCATACGGAAAATGCGTTAATGCTTTATATGGCTTGTACTCACGCTAGCAACCCTGTTTATGCTACGTTGAAGATTAGGATATATTTTTATGACTCTGTAACGAATTGATATTAATAAAGTTTAAATTTTATTTCTGAATATTGATCTACATACATAGTTTGTTGGATTACATTGTACAATACATGTTCTACAGCTTTAATAACTAAATTAATTGAAATTACACCGAGATTGTTCAGATATTTGAGGACTTGGTTTTTGAATACCCTTAAGAAAAGACCAGTCTGAGGCTGTAAGGTCGTCCAGATTCGGAAGGTTAGAAAACACTTGTGCAGTCCCAGAGCTTTCCGCGTGTTGTAGTTGAACTGGATCCTGATCGTGAGTATGTCCATATTCGTCGTGAATGGACGGTTGACGTGGCTGATGATCTTGAAATAAAGGGGATTTGGAACCTCCCAGATATATGCGCCATTCCCTGCTTGAGCTGCAGTGATGGGTTCCCCTGTGCGTGAATCCATGGTTGTGGCAGTTGATTGACAGATAATAAGAACACCCGCATTCAAGATCTACTCTCCTCCTCCTGTTGCGCCTCTTCGCTTCCCTGTGCTGTACTTTGATTGGTACCTGAGTACATGGGTCTATCAAGTGTGATGAAGATCGCATTCTTTAAAGCCCAATTTTTTAGTGCAGAATTCTTCTCTTCATCCAAAAACTCTTTATAGCTAGAATTGGGTCCTGGATTGCAGAGGAAGATGGTGGGAATTCCGCCTTTAATTTGAACTGGCTTCCCGTATTTTGTATTTGATTGCCAGTCCTTTTGGGCCCCCATGAACTCCTTAAAGTGCTTTAGGTAATGTGGGTTGACGTCATCAATGACGTTAAACCAGGCGTCATTACTGTATACCCTTGGGCTCAGATCTAGATGTCCACACAGATAATTATGTGGACCTAATGATCTGGCCCACATCGTCTTCCCCGTCCTACTGTCACCCTCAATCACTACACTTATTGGTCTATTGGCCCGCGCAGCGGCACTGACGACGTTCTCGGCAGCCCACACTTCAAGTTCTTCTGGAACTTGATCGAAAGAAGAAGAGGAAAAAGGAGAAACATAAGGAGCTGGTGGCTCCTGAAAGATTCTGTCTAGATTTGCATTTAAATTATGAAATTGCAGTACAAAATCCTTAGGAGCTAGTTCCTTAATGACTCTAAGAGCCTCCGACTTACTTCCCGCGTTAAGTGCTGCGGCGTAAGCGTCATTGGCTGTCTGTTGCCCTCCTCTTGCTGACCTTCCGTCGATCTGAAATTGCCCCCAGTCGAGAATGTCCCCGTCCTTCTCGGTGTAGGATTTGACGTCGGAGCTGGATTTAGCTCCCTGTATGTTCGGATGGAAATGTGCTGACCTGCTTGGGGAGACCAAGTCGAAGAATCGCATATTCTGGCACTTGAAATTCCCTTCGAACTGGATGAGAACATGCAAGTGAGGAGTCCCATCTTCGTGAAGCTCTCTGCAGATTCTAATATATTTTTTTGAAGTTGGGGTTTGTATATTTAATAATTGGGAAAGTGCTTCCTCTTTGGTGAGAGAACATTTGGGATAAGTGATGAAATAGTTTTTGGAATAAATACCGTTCCGCTTTGGAGGCATGTTGACTAAAATTGATCACCGATTGACCGCTCTTGCAACTCTCCCCGGTATATCGGTGATCAATATATAGTGATCACCAAATGGCATAATGGTAATAAAAAAACTTTAATTTGAAATTCAAACCAAAAGGCTAAAGCGGCCATCCGTTTAATATT

Gene Information

NCBI Accession NP_443740.1
Location 132-488
Gene Name AV2
Protein Name movement/pre-coat protein
Coding Region ATGTGGGATCCACTATTAAACGAATTCCCTGATACGGTTCACGGGTTTCGGTGTATGCTTTCTGTGAAATATTTGCAACTTTTGTCGCAGGATTATTCACCGGATACGCTTGGGTACGAGTTAATACGGGATTTAATTTGTATTTTACGCTCCCGTAGTTATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAG
Protein Sequence MWDPLLNEFPDTVHGFRCMLSVKYLQLLSQDYSPDTLGYELIRDLICILRSRSYVEASCRYRHFYARVESTPASELRQPIHQPCCCPHCPRHKTTGMDKQAYEQEAQDVQDVQKSRCS

NCBI Accession NP_443741.1
Location 292-1062
Gene Name AV1
Protein Name coat protein
Coding Region ATGTCGAAGCGAGCTGCCGATATCGTCATTTCTACGCCCGCGTCGAAAGTACGCCGGCGTCTGAACTTCGGCAGCCCATACACCAGCCGTGCTGCTGCCCCCATTGTCCGCGTCACAAAACAACAGGCATGGACAAACAGGCCTATGAACAGGAAGCCCAGGATGTACAGGATGTACAGAAGTCCAGATGTTCCTAGAGGATGTGAAGGTCCATGTAAGGTTCAGTCGTTTGAGTCCAGACATGATATTCAGCATATAGGTAAAGTAATGTGTGTTAGTGATGTTACTCGTGGTACTGGGCTGACCCATAGAGTTGGTAAGAGATTTTGTGTCAAGTCTGTTTATGTGTTGGGTAAGATATGGATGGATGAGAACATTAAGACGAAGAATCACACGAATAGTGTGATGTTTTTCTTGGTTAGAGATCGTAGACCTGTTGATAAACCTCAAGATTTTGGAGAGGTATTTAATATGTTTGATAATGAGCCCAGTACGGCGACTGTGAAGAATGTTCATCGTGATAGGTATCAAGTTCTGCGCAAATGGTATGCAACTGTCACCGGTGGACAATACGCTTCAAAGGAACAGGCTTTGGTCAAGAAGTTTGTCAGAGTTAACAATTATGTTGTTTACAATCAACAGGAAGCAGGAAAATACGAGAATCATACGGAAAATGCGTTAATGCTTTATATGGCTTGTACTCACGCTAGCAACCCTGTTTATGCTACGTTGAAGATTAGGATATATTTTTATGACTCTGTAACGAATTGA
Protein Sequence MSKRAADIVISTPASKVRRRLNFGSPYTSRAAAPIVRVTKQQAWTNRPMNRKPRMYRMYRSPDVPRGCEGPCKVQSFESRHDIQHIGKVMCVSDVTRGTGLTHRVGKRFCVKSVYVLGKIWMDENIKTKNHTNSVMFFLVRDRRPVDKPQDFGEVFNMFDNEPSTATVKNVHRDRYQVLRKWYATVTGGQYASKEQALVKKFVRVNNYVVYNQQEAGKYENHTENALMLYMACTHASNPVYATLKIRIYFYDSVTN

NCBI Accession NP_443742.1
Location 1065-1469
Gene Name AC3
Protein Name replication enhancer protein
Coding Region ATGGATTCACGCACAGGGGAACCCATCACTGCAGCTCAAGCAGGGAATGGCGCATATATCTGGGAGGTTCCAAATCCCCTTTATTTCAAGATCATCAGCCACGTCAACCGTCCATTCACGACGAATATGGACATACTCACGATCAGGATCCAGTTCAACTACAACACGCGGAAAGCTCTGGGACTGCACAAGTGTTTTCTAACCTTCCGAATCTGGACGACCTTACAGCCTCAGACTGGTCTTTTCTTAAGGGTATTCAAAAACCAAGTCCTCAAATATCTGAACAATCTCGGTGTAATTTCAATTAATTTAGTTATTAAAGCTGTAGAACATGTATTGTACAATGTAATCCAACAAACTATGTATGTAGATCAATATTCAGAAATAAAATTTAAACTTTATTAA
Protein Sequence MDSRTGEPITAAQAGNGAYIWEVPNPLYFKIISHVNRPFTTNMDILTIRIQFNYNTRKALGLHKCFLTFRIWTTLQPQTGLFLRVFKNQVLKYLNNLGVISINLVIKAVEHVLYNVIQQTMYVDQYSEIKFKLY

NCBI Accession NP_443743.1
Location 1162-1614
Gene Name AC2
Protein Name transcription activator protein
Coding Region ATGCGATCTTCATCACACTTGATAGACCCATGTACTCAGGTACCAATCAAAGTACAGCACAGGGAAGCGAAGAGGCGCAACAGGAGGAGGAGAGTAGATCTTGAATGCGGGTGTTCTTATTATCTGTCAATCAACTGCCACAACCATGGATTCACGCACAGGGGAACCCATCACTGCAGCTCAAGCAGGGAATGGCGCATATATCTGGGAGGTTCCAAATCCCCTTTATTTCAAGATCATCAGCCACGTCAACCGTCCATTCACGACGAATATGGACATACTCACGATCAGGATCCAGTTCAACTACAACACGCGGAAAGCTCTGGGACTGCACAAGTGTTTTCTAACCTTCCGAATCTGGACGACCTTACAGCCTCAGACTGGTCTTTTCTTAAGGGTATTCAAAAACCAAGTCCTCAAATATCTGAACAATCTCGGTGTAATTTCAATTAA
Protein Sequence MRSSSHLIDPCTQVPIKVQHREAKRRNRRRRVDLECGCSYYLSINCHNHGFTHRGTHHCSSSREWRIYLGGSKSPLFQDHQPRQPSIHDEYGHTHDQDPVQLQHAESSGTAQVFSNLPNLDDLTASDWSFLKGIQKPSPQISEQSRCNFN

NCBI Accession NP_443744.1
Location 1511-2599
Gene Name AC1
Protein Name replication initiator protein
Coding Region ATGCCTCCAAAGCGGAACGGTATTTATTCCAAAAACTATTTCATCACTTATCCCAAATGTTCTCTCACCAAAGAGGAAGCACTTTCCCAATTATTAAATATACAAACCCCAACTTCAAAAAAATATATTAGAATCTGCAGAGAGCTTCACGAAGATGGGACTCCTCACTTGCATGTTCTCATCCAGTTCGAAGGGAATTTCAAGTGCCAGAATATGCGATTCTTCGACTTGGTCTCCCCAAGCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAATCCTACACCGAGAAGGACGGGGACATTCTCGACTGGGGGCAATTTCAGATCGACGGAAGGTCAGCAAGAGGAGGGCAACAGACAGCCAATGACGCTTACGCCGCAGCACTTAACGCGGGAAGTAAGTCGGAGGCTCTTAGAGTCATTAAGGAACTAGCTCCTAAGGATTTTGTACTGCAATTTCATAATTTAAATGCAAATCTAGACAGAATCTTTCAGGAGCCACCAGCTCCTTATGTTTCTCCTTTTTCCTCTTCTTCTTTCGATCAAGTTCCAGAAGAACTTGAAGTGTGGGCTGCCGAGAACGTCGTCAGTGCCGCTGCGCGGGCCAATAGACCAATAAGTGTAGTGATTGAGGGTGACAGTAGGACGGGGAAGACGATGTGGGCCAGATCATTAGGTCCACATAATTATCTGTGTGGACATCTAGATCTGAGCCCAAGGGTATACAGTAATGACGCCTGGTTTAACGTCATTGATGACGTCAACCCACATTACCTAAAGCACTTTAAGGAGTTCATGGGGGCCCAAAAGGACTGGCAATCAAATACAAAATACGGGAAGCCAGTTCAAATTAAAGGCGGAATTCCCACCATCTTCCTCTGCAATCCAGGACCCAATTCTAGCTATAAAGAGTTTTTGGATGAAGAGAAGAATTCTGCACTAAAAAATTGGGCTTTAAAGAATGCGATCTTCATCACACTTGATAGACCCATGTACTCAGGTACCAATCAAAGTACAGCACAGGGAAGCGAAGAGGCGCAACAGGAGGAGGAGAGTAGATCTTGA
Protein Sequence MPPKRNGIYSKNYFITYPKCSLTKEEALSQLLNIQTPTSKKYIRICRELHEDGTPHLHVLIQFEGNFKCQNMRFFDLVSPSRSAHFHPNIQGAKSSSDVKSYTEKDGDILDWGQFQIDGRSARGGQQTANDAYAAALNAGSKSEALRVIKELAPKDFVLQFHNLNANLDRIFQEPPAPYVSPFSSSSFDQVPEELEVWAAENVVSAAARANRPISVVIEGDSRTGKTMWARSLGPHNYLCGHLDLSPRVYSNDAWFNVIDDVNPHYLKHFKEFMGAQKDWQSNTKYGKPVQIKGGIPTIFLCNPGPNSSYKEFLDEEKNSALKNWALKNAIFITLDRPMYSGTNQSTAQGSEEAQQEEESRS

NCBI Accession NP_443745.1
Location 2143-2445
Gene Name AC4
Protein Name AC4
Coding Region ATGGGACTCCTCACTTGCATGTTCTCATCCAGTTCGAAGGGAATTTCAAGTGCCAGAATATGCGATTCTTCGACTTGGTCTCCCCAAGCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAATCCTACACCGAGAAGGACGGGGACATTCTCGACTGGGGGCAATTTCAGATCGACGGAAGGTCAGCAAGAGGAGGGCAACAGACAGCCAATGACGCTTACGCCGCAGCACTTAACGCGGGAAGTAAGTCGGAGGCTCTTAGAGTCATTAAGGAACTAG
Protein Sequence MGLLTCMFSSSSKGISSARICDSSTWSPQAGQHISIRTYRELNPAPTSNPTPRRTGTFSTGGNFRSTEGQQEEGNRQPMTLTPQHLTREVSRRLLESLRN

References More References in PubMed

1

LbCas12a mediated suppression of Cotton leaf curl Multan virus.

Ashraf S, et al.  Front Plant Sci. 2023 Aug 11;14:1233295. doi: 10.3389/fpls.2023.1233295. eCollection 2023.

PMID: 37636103
2

Cotton leaf curl Multan virus C4 protein suppresses autophagy to facilitate viral infection.

Yang M, et al.  Plant Physiol. 2023 Aug 31;193(1):708-720. doi: 10.1093/plphys/kiad235.

PMID: 37073495
3

Cotton leaf curl Multan virus subverts the processing of hydroxyproline-rich systemin to suppress tobacco defenses against insect vectors.

Chen N, et al.  J Exp Bot. 2024 Sep 27;75(18):5819-5838. doi: 10.1093/jxb/erae257.

PMID: 38829390
4

Prevalence, transmission and molecular characterization of Cotton leaf curl Multan virus infecting hollyhock plants in Pakistan.

Azeem H, et al.  Mol Biol Rep. 2022 Jun;49(6):5635-5644. doi: 10.1007/s11033-022-07557-0. Epub 2022 May 22.

PMID: 35598198
5

Elicitor-Driven Defense Mechanisms: Shielding Cotton Plants against the Onslaught of Cotton Leaf Curl Multan Virus (CLCuMuV) Disease.

Khan MF, et al.  Metabolites. 2023 Nov 12;13(11):1148. doi: 10.3390/metabo13111148.

PMID: 37999244
6

Occurrence of Cotton leaf curl Multan virus and associated betasatellites with leaf curl disease of Bhut-Jolokia chillies (Capsicum chinense Jacq.) in India.

Yogindran S, et al.  Mol Biol Rep. 2021 Mar;48(3):2143-2152. doi: 10.1007/s11033-021-06223-1. Epub 2021 Feb 26.

PMID: 33635470
7

Cotton leaf curl Multan virus differentially regulates innate antiviral immunity of whitefly (Bemisia tabaci) vector to promote cryptic species-dependent virus acquisition.

Farooq T, et al.  Front Plant Sci. 2022 Nov 14;13:1040547. doi: 10.3389/fpls.2022.1040547. eCollection 2022.

PMID: 36452094
8

Cotton Leaf Curl Multan Virus-Derived Viral Small RNAs Can Target Cotton Genes to Promote Viral Infection.

Wang J, et al.  Front Plant Sci. 2016 Aug 4;7:1162. doi: 10.3389/fpls.2016.01162. eCollection 2016.

PMID: 27540385
9

Comparative transcriptome analysis of whiteflies raised on cotton leaf curl Multan virus-infected cotton plants.

Chen T, et al.  Front Vet Sci. 2024 Aug 28;11:1417590. doi: 10.3389/fvets.2024.1417590. eCollection 2024.

PMID: 39263677
10

Molecular phylogenetics and evolutionary analysis of a highly recombinant begomovirus, Cotton leaf curl Multan virus, and associated satellites.

Farooq T, et al.  Virus Evol. 2021 Jun 4;7(2):veab054. doi: 10.1093/ve/veab054. eCollection 2021.

PMID: 34532058