Tobacco leaf rugose virus

Basic Information

Genus Begomovirus
NCBI Assembly GCF_002986915.1
Isolate Cuba:Havana
Release date 2018/8/26
Submitter Dominguez,M., Ramos,P.L., Echemendia,A.L., Peral,R., Crespo,J., Andino,V., Pujol,M., Borroto,C.
Host
Download Genome |GFF3 |PEP |CDS

Genomic Organization

JBrowse

Genome

NC_038890
ACCGGATGGCCGCGCGCCCCCCTTGGTGCCGTACTCCTTTGGTGCGCTTGTGGACCCACACCTAATAATGACAATTTTGTATCGTCCAATCATATTGCGTGTGACGAGCTTAGTTATCTGTGCCAACTTCTTCGGGACCAAGTTAAGAGTGTGGGTCTATAAAAGAATTTGAATTGGCGTTGTTCTTTATGTCAGAATGGTTAAGCGGGACGCTCCTTGGCGCTCGATGGCGGGTCCCTCCAAGGTTAGTCGCAACGCCAATTACTCCCCTCGTGGAGTTTCGGGCCCAAGAGTGAACAAGGCCCAAGCTTGGGTGAACAGGCCCATGTATAGGAAGCCCATGATCTACCGGATGTTGAGAGGCCCCGATATTCCTAAGGGCTGTGAAGGTCCTTGTAAGGTCCAATCTTATGAGCAGCGACATGACATCTCCCATGTCGGCAAGGTCATGTGCATATCCGATGTGACGCGTGGTAATGGTATTACCCATCGTGTGGGTAAGCGTTTTTGTGTTAAGTCTGTGTATATCTTAGGTAAGATATGGATGGACGAAAACATCAAGTTGAAGAACCACACGAACAGCGTCATGTTCTGGTTGGTCAGGGACCGTAGACCCTATGGCACCCCTATGGACTTTGGCCAGGTGTTTAACATGTTCGACAACGAGCCTAGCACGGCTACCGTGAAGAACGATCTCCGCGATCGTTACCAGGTCATGCACAGGTTCTATGCCAAAGTCACAGGTGGACAGTACGCCAGCAACGAGCAGGCATTGGTTAGGCGATTCTGGAAGGTGAACAACCACGTGGTCTACAACCACCAGGAAGCTGGCAAGTACGAGAACCACACCGAGAACGCCCTTTTATTGTATATGGCATGTACTCATGCGTCTAACCCTGTGTATGCAACTCTGAAGATTCGGATCTATTTTTACGATTCGATCATGAATTAATAAATTTTGAATTTTATTGAATGATTTTCCAGTACATAATTTACATACGTTCTGTCCGTCGCGAATCGTACAGCTCTAATTACATTGTTAACTGAAATCACGCCTAACTGATCTAAATACAAGTTGACTAAGTGCCTAAACCTAGCTAAATATGTCTGCCCAGAAGCTGTCAGGGAAGTCGTCCAGACTTGGAAGTTCATGTACGCCTTGTGGAGATCCAACGCTCTCCTCAGGTTGTGGCTGAACCGTATCTGGATGTGGTATACTCTGGTCCTGGTGTACAGCGGGTCCTCTACCCTGTACATCCTGAAATAGAGGGGATTTTCTATCTCCCAGATATACACGCCATTCTCCGCCTGATGTGCAGTGATGAGTTCCCCTGTGCGTGAATCCATGCCCGGTACAGCCTATGTGGAAGTAGATGGAGCACCCGCACTGTAAATCAATCCTGCGTCTCCTGATTGCCCTCCTTTTCTTGTATTGTCTGTGCGCCTTCTTGATAGAGGGGGGCTGTGAGGGTGATGAAGACCGCATTCTTGATGGTCCAGTTTCTGAGTGATGCGTTTTCCTCTTTGTCGAGGAAATCTTTATAGCTGGCACCCTCACCAGGATTGCAAAGCACGATTGATGGGATTCCTCCTTTAATTTGAACTGGCTTGCCGTATTTGCAATTTGACTGCCAGTCCTTCTGGGCCCCCAGAAGTTCTTTCCAGTGCTTTAGCTTTAGATAGTGCGGTGCGACGTCATCAATGACGTTATAATCCACTTCGTTTGAATAGACCCGGGCATTGAAGTCCAGGTGTCCACTGAGATAGTTATGCGGGCCCAATGAACGAGCCCACATGGTCTTTCCCGTCCTTGAATCACCTTCAACTATGATACTCAGTGGTCTTTCTGGCCGCGCAGAACCTCTTCCAAAATAATCATCCGCCCACTCTTGCATGTCTTCCGGAACGTTAGTGAACGAGGAGAGTTGAAACGGAGGAACCCATTGTTCTGGAGCCTTTGCGAATATCCTTTCTAAGTTGGAGCGGATGTTATGATTCTGCAGGACAAAATCTTTTGGCTGTTCTTCCCTTAAAACCGCCATGGCAGACTGAACAGAGTCTGCATTTAACGCCTTGGCATATGAATCATTAGCAGACTGCTTGCCTCCTCTAGCAGATCTGCCGTCGATCTGGAATTCTCCCCATTCCAGTGTATCTCCGTCCTTGTCGATGTAGGACTTGACGTCGGAGCTGGATTTAGCTCCCTGTATGTTCGGATGGAAATGTGCTGACCTGGTTGGGGAGACCAGATCGAAGAATCTGTTATTCTTGCACTGGTATTTTCCCTCGAACTGTATAAGCACATGGAGATGAGGCTCCCCATTCTCATGCAGTTCTCTGCAGATTTTGATGAACTTCTTGTTAACTGGTGTTTCTAGGTTTTGTAATTGGGAAAGTGCCTCTTCTTTTGGAAGAGAGCACTGCGGATAAGTGATGAAATTAGTTTTTGGCTGAGATTTGAAACGCTTGACTGATGGCATTTTTTGTAATAAGAAGGGAGACCCCAATTGAGCTCTCTCTAAACTTGCTATATGAATTGGGGTCTGGGGTCTCATTTATACTAGAAGGCTCAATAGAACTCTCAATCTCGTTCGCACACGTGCGGCCATCCGATATAATATT

Gene Information

NCBI Accession YP_009508160.1
Location 197-952
Gene Name AV1
Protein Name coat protein
Coding Region ATGGTTAAGCGGGACGCTCCTTGGCGCTCGATGGCGGGTCCCTCCAAGGTTAGTCGCAACGCCAATTACTCCCCTCGTGGAGTTTCGGGCCCAAGAGTGAACAAGGCCCAAGCTTGGGTGAACAGGCCCATGTATAGGAAGCCCATGATCTACCGGATGTTGAGAGGCCCCGATATTCCTAAGGGCTGTGAAGGTCCTTGTAAGGTCCAATCTTATGAGCAGCGACATGACATCTCCCATGTCGGCAAGGTCATGTGCATATCCGATGTGACGCGTGGTAATGGTATTACCCATCGTGTGGGTAAGCGTTTTTGTGTTAAGTCTGTGTATATCTTAGGTAAGATATGGATGGACGAAAACATCAAGTTGAAGAACCACACGAACAGCGTCATGTTCTGGTTGGTCAGGGACCGTAGACCCTATGGCACCCCTATGGACTTTGGCCAGGTGTTTAACATGTTCGACAACGAGCCTAGCACGGCTACCGTGAAGAACGATCTCCGCGATCGTTACCAGGTCATGCACAGGTTCTATGCCAAAGTCACAGGTGGACAGTACGCCAGCAACGAGCAGGCATTGGTTAGGCGATTCTGGAAGGTGAACAACCACGTGGTCTACAACCACCAGGAAGCTGGCAAGTACGAGAACCACACCGAGAACGCCCTTTTATTGTATATGGCATGTACTCATGCGTCTAACCCTGTGTATGCAACTCTGAAGATTCGGATCTATTTTTACGATTCGATCATGAATTAA
Protein Sequence MVKRDAPWRSMAGPSKVSRNANYSPRGVSGPRVNKAQAWVNRPMYRKPMIYRMLRGPDIPKGCEGPCKVQSYEQRHDISHVGKVMCISDVTRGNGITHRVGKRFCVKSVYILGKIWMDENIKLKNHTNSVMFWLVRDRRPYGTPMDFGQVFNMFDNEPSTATVKNDLRDRYQVMHRFYAKVTGGQYASNEQALVRRFWKVNNHVVYNHQEAGKYENHTENALLLYMACTHASNPVYATLKIRIYFYDSIMN

NCBI Accession YP_009508161.1
Location 949-1347
Gene Name AC3
Protein Name replication enhancement protein
Coding Region ATGGATTCACGCACAGGGGAACTCATCACTGCACATCAGGCGGAGAATGGCGTGTATATCTGGGAGATAGAAAATCCCCTCTATTTCAGGATGTACAGGGTAGAGGACCCGCTGTACACCAGGACCAGAGTATACCACATCCAGATACGGTTCAGCCACAACCTGAGGAGAGCGTTGGATCTCCACAAGGCGTACATGAACTTCCAAGTCTGGACGACTTCCCTGACAGCTTCTGGGCAGACATATTTAGCTAGGTTTAGGCACTTAGTCAACTTGTATTTAGATCAGTTAGGCGTGATTTCAGTTAACAATGTAATTAGAGCTGTACGATTCGCGACGGACAGAACGTATGTAAATTATGTACTGGAAAATCATTCAATAAAATTCAAAATTTATTAA
Protein Sequence MDSRTGELITAHQAENGVYIWEIENPLYFRMYRVEDPLYTRTRVYHIQIRFSHNLRRALDLHKAYMNFQVWTTSLTASGQTYLARFRHLVNLYLDQLGVISVNNVIRAVRFATDRTYVNYVLENHSIKFKIY

NCBI Accession YP_009508162.1
Location 1094-1486
Gene Name AC2
Protein Name transactivator protein
Coding Region ATGCGGTCTTCATCACCCTCACAGCCCCCCTCTATCAAGAAGGCGCACAGACAATACAAGAAAAGGAGGGCAATCAGGAGACGCAGGATTGATTTACAGTGCGGGTGCTCCATCTACTTCCACATAGGCTGTACCGGGCATGGATTCACGCACAGGGGAACTCATCACTGCACATCAGGCGGAGAATGGCGTGTATATCTGGGAGATAGAAAATCCCCTCTATTTCAGGATGTACAGGGTAGAGGACCCGCTGTACACCAGGACCAGAGTATACCACATCCAGATACGGTTCAGCCACAACCTGAGGAGAGCGTTGGATCTCCACAAGGCGTACATGAACTTCCAAGTCTGGACGACTTCCCTGACAGCTTCTGGGCAGACATATTTAGCTAG
Protein Sequence MRSSSPSQPPSIKKAHRQYKKRRAIRRRRIDLQCGCSIYFHIGCTGHGFTHRGTHHCTSGGEWRVYLGDRKSPLFQDVQGRGPAVHQDQSIPHPDTVQPQPEESVGSPQGVHELPSLDDFPDSFWADIFS

NCBI Accession YP_009508163.1
Location 1395-2480
Gene Name AC1
Protein Name replication associated protein
Coding Region ATGCCATCAGTCAAGCGTTTCAAATCTCAGCCAAAAACTAATTTCATCACTTATCCGCAGTGCTCTCTTCCAAAAGAAGAGGCACTTTCCCAATTACAAAACCTAGAAACACCAGTTAACAAGAAGTTCATCAAAATCTGCAGAGAACTGCATGAGAATGGGGAGCCTCATCTCCATGTGCTTATACAGTTCGAGGGAAAATACCAGTGCAAGAATAACAGATTCTTCGATCTGGTCTCCCCAACCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAGTCCTACATCGACAAGGACGGAGATACACTGGAATGGGGAGAATTCCAGATCGACGGCAGATCTGCTAGAGGAGGCAAGCAGTCTGCTAATGATTCATATGCCAAGGCGTTAAATGCAGACTCTGTTCAGTCTGCCATGGCGGTTTTAAGGGAAGAACAGCCAAAAGATTTTGTCCTGCAGAATCATAACATCCGCTCCAACTTAGAAAGGATATTCGCAAAGGCTCCAGAACAATGGGTTCCTCCGTTTCAACTCTCCTCGTTCACTAACGTTCCGGAAGACATGCAAGAGTGGGCGGATGATTATTTTGGAAGAGGTTCTGCGCGGCCAGAAAGACCACTGAGTATCATAGTTGAAGGTGATTCAAGGACGGGAAAGACCATGTGGGCTCGTTCATTGGGCCCGCATAACTATCTCAGTGGACACCTGGACTTCAATGCCCGGGTCTATTCAAACGAAGTGGATTATAACGTCATTGATGACGTCGCACCGCACTATCTAAAGCTAAAGCACTGGAAAGAACTTCTGGGGGCCCAGAAGGACTGGCAGTCAAATTGCAAATACGGCAAGCCAGTTCAAATTAAAGGAGGAATCCCATCAATCGTGCTTTGCAATCCTGGTGAGGGTGCCAGCTATAAAGATTTCCTCGACAAAGAGGAAAACGCATCACTCAGAAACTGGACCATCAAGAATGCGGTCTTCATCACCCTCACAGCCCCCCTCTATCAAGAAGGCGCACAGACAATACAAGAAAAGGAGGGCAATCAGGAGACGCAGGATTGA
Protein Sequence MPSVKRFKSQPKTNFITYPQCSLPKEEALSQLQNLETPVNKKFIKICRELHENGEPHLHVLIQFEGKYQCKNNRFFDLVSPTRSAHFHPNIQGAKSSSDVKSYIDKDGDTLEWGEFQIDGRSARGGKQSANDSYAKALNADSVQSAMAVLREEQPKDFVLQNHNIRSNLERIFAKAPEQWVPPFQLSSFTNVPEDMQEWADDYFGRGSARPERPLSIIVEGDSRTGKTMWARSLGPHNYLSGHLDFNARVYSNEVDYNVIDDVAPHYLKLKHWKELLGAQKDWQSNCKYGKPVQIKGGIPSIVLCNPGEGASYKDFLDKEENASLRNWTIKNAVFITLTAPLYQEGAQTIQEKEGNQETQD

NCBI Accession YP_009508164.1
Location 2066-2329
Gene Name AC4
Protein Name AC4 protein
Coding Region ATGAGAATGGGGAGCCTCATCTCCATGTGCTTATACAGTTCGAGGGAAAATACCAGTGCAAGAATAACAGATTCTTCGATCTGGTCTCCCCAACCAGGTCAGCACATTTCCATCCGAACATACAGGGAGCTAAATCCAGCTCCGACGTCAAGTCCTACATCGACAAGGACGGAGATACACTGGAATGGGGAGAATTCCAGATCGACGGCAGATCTGCTAGAGGAGGCAAGCAGTCTGCTAATGATTCATATGCCAAGGCGTTAA
Protein Sequence MRMGSLISMCLYSSRENTSARITDSSIWSPQPGQHISIRTYRELNPAPTSSPTSTRTEIHWNGENSRSTADLLEEASSLLMIHMPRR

References More References in PubMed

1

Tomato brown rugose fruit virus: An emerging and rapidly spreading plant RNA virus that threatens tomato production worldwide.

Zhang S, et al.  Mol Plant Pathol. 2022 Sep;23(9):1262-1277. doi: 10.1111/mpp.13229. Epub 2022 May 22.

PMID: 35598295
2

Molecular Characterization of Tobacco leaf rugose virus, a New Begomovirus Infecting Tobacco in Cuba.

Domínguez M, et al.  Plant Dis. 2002 Sep;86(9):1050. doi: 10.1094/PDIS.2002.86.9.1050A.

PMID: 30818540
3

The N gene protects tomato plants from tomato brown rugose fruit virus infection.

Zhou J, et al.  Plant Biotechnol J. 2025 Oct;23(10):4339-4349. doi: 10.1111/pbi.70237. Epub 2025 Jul 2.

PMID: 40601793
4

Tomato severe rugose virus: Another Begomovirus Causing Leaf Deformation and Mosaic Symptoms on Potato in Brazil.

Souza-Dias JAC, et al.  Plant Dis. 2008 Mar;92(3):487. doi: 10.1094/PDIS-92-3-0487C.

PMID: 30769698
5

Identification and management of tomato brown rugose fruit virus in greenhouses in Mexico.

Vargas-Mejía P, et al.  Arch Virol. 2023 Apr 12;168(5):135. doi: 10.1007/s00705-023-05757-y.

PMID: 37043016
6

Comparison of Models for Quantification of Tomato Brown Rugose Fruit Virus Based on a Bioassay Using a Local Lesion Host.

Nourinejhad Zarghani S, et al.  Plants (Basel). 2022 Dec 9;11(24):3443. doi: 10.3390/plants11243443.

PMID: 36559554
7

Identification of genetic determinants of tomato brown rugose fruit virus that enable infection of plants harbouring the Tm-2(2) resistance gene.

Yan ZY, et al.  Mol Plant Pathol. 2021 Nov;22(11):1347-1357. doi: 10.1111/mpp.13115. Epub 2021 Aug 13.

PMID: 34390124
8

Screening of Solanum (sections Lycopersicon and Juglandifolia) germplasm for reactions to the tomato brown rugose fruit virus (ToBRFV).

Jewehan A, et al.  J Plant Dis Prot (2006). 2022;129(1):117-123. doi: 10.1007/s41348-021-00535-x. Epub 2021 Oct 9.

PMID: 34659580
9

Leaf Plasmodesmata Respond Differently to TMV, ToBRFV and TYLCV Infection.

Kutsher Y, et al.  Plants (Basel). 2021 Jul 14;10(7):1442. doi: 10.3390/plants10071442.

PMID: 34371642
10

Comprehensive Ubiquitome Analysis of Nicotiana benthamiana Leaves Infected with Tomato Brown Rugose Fruit Virus.

Yang J, et al.  Biology (Basel). 2025 Jun 5;14(6):656. doi: 10.3390/biology14060656.

PMID: 40563907